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Details on Person UniProt:Q9BQE4 SELENOS
| Class:Id | ReferenceGeneProduct:101375 |
|---|---|
| _chainChangeLog | chain:1-189 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BQE4 SELENOS |
| _timestamp | 2024-11-03 19:58:30 |
| chain | chain:1-189 |
| checksum | 720DDCC597A7135A |
| comment | FUNCTION Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination.SUBUNIT Interacts with DERL1 and (via VIM motif) with VCP, suggesting that it forms a membrane complex with DERL1 that serves as a receptor for VCP. Also interacts with DERL2, DERL3 and SELENOK. The SELENOK-SELENOS complex interacts with VCP. Interacts with CCDC47 (By similarity).INTERACTION Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins (PubMed:26138980, PubMed:30526872). Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex (PubMed:32200094).SIMILARITY Belongs to the selenoprotein S family.SEQUENCE CAUTION Truncated C-terminus. |
| description | recommendedName: fullName evidence="15"Selenoprotein S shortName evidence="13"SelS alternativeName: fullName evidence="14"VCP-interacting membrane protein |
| geneName | SELENOS SELS VIMP AD-015 SBBI8 |
| identifier | Q9BQE4 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Endoplasmic reticulum Membrane Phosphoprotein Proteomics identification Reference proteome Selenocysteine Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SELENOS |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990971] ENSEMBL:ENSG00000131871 SELENOS [Homo sapiens] |
| secondaryIdentifier | SELS_HUMAN Q3B771 Q9P0I6 |
| sequenceLength | 189 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8943099] VIMP [endoplasmic reticulum membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9BQE4 SELENOS (101375)
