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Details on Person UniProt:Q96EE3-1 SEH1L
| Class:Id | ReferenceIsoform:101356 |
|---|---|
| _chainChangeLog | chain:1-360 added on Sat February 7 2015 |
| _displayName | UniProt:Q96EE3-1 SEH1L |
| _timestamp | 2024-11-03 19:43:24 |
| chain | chain:1-360 |
| checksum | FB9ED2440C4EC9AB |
| comment | FUNCTION Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (PubMed:15146057, PubMed:17363900). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (PubMed:15146057, PubMed:17363900).FUNCTION As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510).ACTIVITY REGULATION The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids (PubMed:25457612, PubMed:26972053, PubMed:27487210, PubMed:35831510). In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated (PubMed:25457612, PubMed:26972053, PubMed:27487210, PubMed:35831510).SUBUNIT Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC) (PubMed:17360435). The Nup107-160 subcomplex includes NUP160, NUP133, NUP107, NUP98, NUP85, NUP43, NUP37, SEH1 and SEC13 (PubMed:17360435). The SEH1 subunit appears to be only weakly associated with the Nup107-160 subcomplex (PubMed:17360435). Component of the GATOR2 subcomplex, composed of MIOS, SEC13, SEH1L, WDR24 and WDR59 (PubMed:23723238). The GATOR2 complex interacts with CASTOR1 and CASTOR2; the interaction is negatively regulated by arginine (PubMed:26972053, PubMed:35831510, PubMed:36528027). The GATOR2 complex interacts with SESN1, SESN2 and SESN3; the interaction is negatively regulated by amino acids (PubMed:25263562, PubMed:25457612). SESN1, SESN2 and SESN3 convey leucine availability via direct interaction with SEH1L and WDR24 (PubMed:35831510).INTERACTION Belongs to the WD repeat SEC13 family.CAUTION The E3 ubiquitin-protein ligase activity of the GATOR2 complex is subject to discussion (PubMed:35831510, PubMed:36528027). According to a report, the GATOR2 complex does not catalyze ubiquitination of the GATOR1 complex (PubMed:35831510). In contrast, another publication showed that the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). |
| description | recommendedName: fullName evidence="17"Nucleoporin SEH1 alternativeName: fullName evidence="17"GATOR2 complex protein SEH1 alternativeName: Nup107-160 subcomplex subunit SEH1 alternativeName: SEC13-like protein |
| geneName | SEH1L SEC13L SEH1 |
| identifier | Q96EE3 |
| isoformParent | |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell cycle Cell division Centromere Chromosome Chromosome partition Isopeptide bond Kinetochore Lysosome Membrane Mitosis mRNA transport Nuclear pore complex Nucleus Phosphoprotein Protein transport Proteomics identification Reference proteome Repeat Translocation Transport Ubl conjugation WD repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | SEH1L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999148] ENSEMBL:ENSG00000085415 SEH1L [Homo sapiens] |
| secondaryIdentifier | SEH1_HUMAN A8K5B1 Q8NFU6 Q96MH3 Q9C069 |
| sequenceLength | 360 |
| species | [Species:48887] Homo sapiens |
| variantIdentifier | Q96EE3-1 |
| (referenceEntity) | [EntityWithAccessionedSequence:376246] SEH1L-1 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q96EE3-1 SEH1L (101356)
