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Details on Person Activation of GIRK/Kir3 Channels

Class:Id	Reaction:1013020
_displayName	Activation of GIRK/Kir3 Channels
_doRelease	TRUE
_timestamp	2011-05-27 16:16:52
authored	[InstanceEdit:1013009] Mahajan, SS, 2010-11-11
catalystActivity	[CatalystActivity:1013015] G-protein activated inward rectifier potassium channel activity of GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane]
compartment	[Compartment:70101] cytosol [Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:1013009] Mahajan, SS, 2010-11-11
edited	[InstanceEdit:386897] Mahajan, SS, 2008-11-27 12:40:45
input	[SimpleEntity:29804] K+ [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:1013797] Evidence for association of GABA(B) receptors with Kir3 channels and regulators of G protein signalling (RGS4) proteins
modified	[InstanceEdit:1013830] Mahajan, SS, 2010-11-12 [InstanceEdit:1045159] D'Eustachio, P, 2010-11-22 [InstanceEdit:1097353] Matthews, L, 2010-11-30 [InstanceEdit:1297449] Mahajan, SS, 2011-05-22 [InstanceEdit:1299242] Mahajan, SS, 2011-05-22 [InstanceEdit:1299517] Mahajan, SS, 2011-05-23 [InstanceEdit:1306925] Mahajan, SS, 2011-05-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Activation of GIRK/Kir3 Channels
output	[SimpleEntity:74126] K+ [extracellular region]
precedingEvent	[Reaction:1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels [Homo sapiens] [Reaction:1013013] Association of GABA B receptor with G protein beta-gamma subunits [Homo sapiens] [Reaction:420688] GABAB heterodimeric receptor binds GABA [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104628] R-HSA-1013020.2
summation	[Summation:1013805] Binding of G beta gamma activates the GIRK/Kir3 channels tha...
(hasEvent)	[Pathway:997272] Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits [Homo sapiens] [Pathway:1296041] Activation of G protein gated Potassium channels [Homo sapiens]
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No pathways have been reviewed or authored by Activation of GIRK/Kir3 Channels (1013020)