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Details on Person Association of GABA B receptor with G protein beta-gamma subunits

Class:Id	Reaction:1013013
_displayName	Association of GABA B receptor with G protein beta-gamma subunits
_doRelease	TRUE
_timestamp	2020-01-02 17:04:14
authored	[InstanceEdit:1063707] Mahajan, SS, 2010-11-25
catalystActivity	[CatalystActivity:1013016] G protein-coupled GABA receptor activity of GABBR1:GABBR2:GABA [plasma membrane]
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:1013009] Mahajan, SS, 2010-11-11
edited	[InstanceEdit:1056679] D'Eustachio, P, 2010-11-24
input	[Complex:420698] GABBR1:GABBR2:GABA [plasma membrane] [Homo sapiens] [Complex:167434] G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1013766] Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling
modified	[InstanceEdit:1013826] Mahajan, SS, 2010-11-12 [InstanceEdit:1056684] D'Eustachio, P, 2010-11-24 [InstanceEdit:1094924] D'Eustachio, P, 2010-11-30 [InstanceEdit:1094926] D'Eustachio, P, 2010-11-30 [InstanceEdit:1297447] Mahajan, SS, 2011-05-22 [InstanceEdit:1299528] Mahajan, SS, 2011-05-23 [InstanceEdit:8879177] Wu, G, 2016-07-15 [InstanceEdit:8979364] Gillespie, Marc E, 2017-02-24 [InstanceEdit:9605730] Orlic-Milacic, Marija, 2018-04-17 [InstanceEdit:9632636] D'Eustachio, Peter, 2018-12-20 [InstanceEdit:9672728] Jassal, Bijay, 2020-01-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Association of GABA B receptor with G protein beta-gamma subunits
output	[Complex:1013017] GABA B receptor G-protein beta-gamma complex [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:420688] GABAB heterodimeric receptor binds GABA [Homo sapiens] [Reaction:888589] Release of GABA at the synapse [Homo sapiens]
releaseDate	2010-12-14
reviewed	[InstanceEdit:386898] Restituito, S, 2008-11-27 12:38:49
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:8886750] R-HSA-1013013.3
summation	[Summation:1013806] Activation of GABA B receptors by GABA stimulates Gi/o prote...
(hasEvent)	[Pathway:997272] Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits [Homo sapiens] [Pathway:1296041] Activation of G protein gated Potassium channels [Homo sapiens]
(precedingEvent)	[Reaction:1013012] Binding of Gbeta/gamma to GIRK/Kir3 channels [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777083] Update Tracker - [Reaction:1013013] Association of GABA B receptor with G protein beta-gamma subunits - v72:[add_removeInput]
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