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Details on Person UniProt:P52870 SBH1
| Class:Id | ReferenceGeneProduct:101078 |
|---|---|
| _chainChangeLog | chain:1-82 added on Fri February 6 2015 |
| _displayName | UniProt:P52870 SBH1 |
| _timestamp | 2023-11-03 15:52:12 |
| chain | chain:1-82 |
| checksum | 23B0313EB37744FA |
| comment | FUNCTION Part of the Sec61 complex, which is the major component of a channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). The functional states of the translocon complex include co- and post-translational ER import, cotranslational membrane protein integration and retrograde transport of misfolded proteins out of the ER. In the cotranslational pathway, ribosomes synthesizing presecretory proteins are targeted to the translocon by the cytosolic signal recognition particle (SRP) and its ER-localized receptor. The association of the Sec61 complex with the ribosome is mediated by the 28S rRNA of the large ribosomal subunit. SRP-independent post-translational translocation requires the association of additional factors, such as the Sec62/63 complex and KAR2.SUBUNIT Component of the heterotrimeric Sec61 complex, which is composed of SSH1, SBH1 and SSS1. Presumably three to four Sec61 heterotrimers assemble into an oligomeric ring with a central aqueous pore. In cotranslational ER import, the pore diameter varies from 9-15 A in a ribosome-free resting state to 40-60 A in a functional state when associated with the ribosome. The Sec61 complex is part of a channel-forming translocon complex whose composition seem to change dependent upon different functional states. During post-translational ER import the Sec61 complex associates with the Sec62/63 complex to form the Sec complex. SBH1 interacts OST2, OST4 and WBP1 components of the OT complex.INTERACTION Belongs to the SEC61-beta family. |
| description | recommendedName: Protein transport protein SBH1 alternativeName: Sec61 complex subunit SBH1 alternativeName: Sec61 complex subunit beta |
| geneName | SBH1 SEB1 YER087C-B YER087BC |
| identifier | P52870 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Endoplasmic reticulum Membrane Protein transport Reference proteome Translocation Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5083144] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 |
| name | SBH1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | SC6B1_YEAST D3DLZ4 |
| sequenceLength | 82 |
| species | [Species:68322] Saccharomyces cerevisiae |
| (referenceEntity) | [EntityWithAccessionedSequence:9628639] SBH1 [endoplasmic reticulum membrane] [Saccharomyces cerevisiae] [EntityWithAccessionedSequence:9628663] SBH1 [cytosol] [Saccharomyces cerevisiae] |
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No pathways have been reviewed or authored by UniProt:P52870 SBH1 (101078)
