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Details on Person UniProt:P46948 SKI6
| Class:Id | ReferenceGeneProduct:100580 |
|---|---|
| _chainChangeLog | chain:1-246 added on Sat February 7 2015 |
| _displayName | UniProt:P46948 SKI6 |
| _timestamp | 2025-02-21 19:01:19 |
| chain | chain:1-246 |
| checksum | C80EFFB528A43044 |
| comment | FUNCTION Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. SKI6 is part of the hexameric ring of RNase PH domain-containing subunits proposed to form a central channel which threads RNA substrates for degradation.SUBUNIT Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.INTERACTION Present with 5150 molecules/cell in log phase SD medium.SIMILARITY Belongs to the RNase PH family.CAUTION Was originally thought to have exonuclease activity but it was later shown (PubMed:17173052, PubMed:17174896) that only DIS3/RRP44 subunit of the exosome core has this activity. |
| description | recommendedName: Exosome complex component SKI6 alternativeName: Extracellular mutant protein 20 alternativeName: Ribosomal RNA-processing protein 41 alternativeName: Superkiller protein 6 |
| geneName | SKI6 ECM20 RRP41 YGR195W G7587 |
| identifier | P46948 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cytoplasm Exosome Nucleus Reference proteome RNA-binding rRNA processing |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9834092] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SKI6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | RRP41_YEAST D6VUX7 |
| sequenceLength | 246 |
| species | [Species:68322] Saccharomyces cerevisiae |
| (referenceEntity) | [EntityWithAccessionedSequence:8931504] SKI6 [cytosol] [Saccharomyces cerevisiae] |
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No pathways have been reviewed or authored by UniProt:P46948 SKI6 (100580)
