Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person UniProt:P11930 Nudt19

Class:Id	ReferenceGeneProduct:100453
_chainChangeLog	transit peptide:1-9 added on Fri February 6 2015;chain:10-357 added on Fri February 6 2015;transit peptide:1-9 removed on Fri February 12 2016;chain:10-357 removed on Fri February 12 2016;chain:1-357 added on Fri February 12 2016
_displayName	UniProt:P11930 Nudt19
_timestamp	2025-02-21 18:49:47
chain	chain:1-357
checksum	6ED30EC4BF2955FE
comment	FUNCTION Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (PubMed:16185196, PubMed:29378847). Mediates the hydrolysis of a wide range of CoA esters, including choloyl-CoA and branched-chain fatty-acyl-CoA esters and at low substrate concentrations medium and long-chain fatty-acyl-CoA esters are the primary substrates (PubMed:16185196, PubMed:29378847). Highest activity seen with medium-chain acyl-CoA esters and higher rates of activity seen with the unsaturated acyl-CoA esters compared with the saturated esters (PubMed:16185196). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673).CATALYTIC ACTIVITY an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY hexanoyl-CoA + H2O = hexanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY octanoyl-CoA + H2O = S-octanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY butanoyl-CoA + H2O = S-butanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY propanoyl-CoA + H2O = propanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY malonyl-CoA + H2O = malonyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY succinyl-CoA + H2O = succinyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY choloyl-CoA + H2O = S-choloyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY 4,8-dimethylnonanoyl-CoA + H2O = S-(4,8-dimethylnonanoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z,12Z,15Z)-octadecatrienoyl-CoA + H2O = S-(9Z,12Z,15Z-octadecatrienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z,12Z)-octadecadienoyl-CoA + H2O = S-(9Z,12Z-octadecadienoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z)-hexadecenoyl-CoA + H2O = S-(9Z-hexadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (9Z)-tetradecenoyl-CoA + H2O = S-(9Z-tetradecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY (6Z)-octenoyl-CoA + H2O = S-(6Z-octenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY tetradecanoyl-CoA + H2O = tetradecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY dodecanoyl-CoA + H2O = S-dodecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)CATALYTIC ACTIVITY a 5'-end CoA-ribonucleoside in mRNA + H2O = a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + (R)-4'-phosphopantetheine + 2 H(+)COFACTOR Inhibited by chenodeoxycholic acid (CDCA) and its conjugated derivatives, taurochenodeoxycholic acid and glycochenodeoxycholic acid (PubMed:29378847). Inhibited by fluoride (PubMed:16185196).BIOPHYSICOCHEMICAL PROPERTIES Optimum pH is 9.0.SUBUNIT Monomer.SUBCELLULAR LOCATION Highly expressed in the kidneys, with lower levels in skeletal muscle and brain (at protein level).INDUCTION By testosterone.DISRUPTION PHENOTYPE Mice exhibit a significant 20% increase in total CoA levels in kidney.SIMILARITY Belongs to the Nudix hydrolase family.
description	recommendedName: fullName evidence="8"Acyl-coenzyme A diphosphatase NUDT19 ecNumber: 3.6.1.- ecNumber evidence="4 5"3.6.1.77 alternativeName: Androgen-regulated protein RP2 alternativeName: Nucleoside diphosphate-linked moiety X motif 19 shortName: Nudix motif 19 alternativeName: fullName evidence="8"Renal CoA diphosphohydrolase alternativeName: Testosterone-regulated RP2 protein shortName: RP2p
geneName	Nudt19 D7Rp2e
identifier	P11930
isSequenceChanged	FALSE
keyword	Hydrolase Magnesium Manganese Metal-binding Peroxisome Reference proteome
modified	[InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:8856987] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9767224] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21
name	Nudt19
referenceDatabase	[ReferenceDatabase:2] UniProt
secondaryIdentifier	NUD19_MOUSE B2RS21
sequenceLength	357
species	[Species:48892] Mus musculus
(referenceEntity)	[EntityWithAccessionedSequence:6810524] Nudt19 [peroxisomal matrix] [Mus musculus]
[Change default viewing format]

No pathways have been reviewed or authored by UniProt:P11930 Nudt19 (100453)