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Details on Person UniProt:Q9Z138 Ror2
| Class:Id | ReferenceGeneProduct:100440 |
|---|---|
| _chainChangeLog | signal peptide:1-33 added on Fri February 6 2015;chain:34-944 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Z138 Ror2 |
| _timestamp | 2025-02-21 19:01:17 |
| chain | signal peptide:1-33 chain:34-944 |
| checksum | 03B00784CFFF4489 |
| comment | FUNCTION Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (PubMed:10700181). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation. In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (By similarity).CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Homodimer; promotes osteogenesis. Binds YWHAB (By similarity). Interacts with WTIP (PubMed:19785987). Interacts with ROR2 (By similarity).SUBCELLULAR LOCATION From 9.5 to 11.5 dpc, expressed in the branchial arches, otic vesicle, limb buds, somites, craniofacial mesenchyme and tail buds. At 14.5 dpc, expressed in the developing tongue, nasal cavity, palate, adrenal gland, in the forebrain, dorsal root ganglia and in the somites. At 14.5 dpc, also detected in lung, rib cartilage, kidney and intestine (at protein level).SIMILARITY Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. |
| description | recommendedName: Tyrosine-protein kinase transmembrane receptor ROR2 shortName: mROR2 ecNumber evidence="2"2.7.10.1 alternativeName: Neurotrophic tyrosine kinase, receptor-related 2 |
| geneName | Ror2 |
| identifier | Q9Z138 |
| isSequenceChanged | FALSE |
| keyword | ATP-binding Cell membrane Developmental protein Disulfide bond Glycoprotein Immunoglobulin domain Kinase Kringle Magnesium Membrane Metal-binding Methylation Nucleotide-binding Phosphoprotein Receptor Reference proteome Signal Transferase Transmembrane Transmembrane helix Wnt signaling pathway |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:3445779] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:6807888] Weiser, JD [InstanceEdit:8944791] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9730071] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | Ror2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | ROR2_MOUSE E9QKB3 |
| sequenceLength | 944 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:4551498] Ror2 [plasma membrane] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:Q9Z138 Ror2 (100440)
